THE USE OF FATTY ACIDS IN INFLAMMATORY DISEASE
Research has studied the use of specific fatty acids on the immune system and the effect on inflammatory disease of the skin and musculo-skeletal system. Current dietary recommendations are to provide additional levels of Omega-6 (GLA) or Omega-3 (ALA), EPA, and DHA for dermatitis, pruritus, arthritis, and other inflammatory diseases.
From Small Animal Clinical Nutrition: 4th Edition:
Use of Fatty Acids in Inflammatory Diseases: Consumption of fish oil with n-3 PUFA or oils high in the n-6 fatty acid GLA (e.g. evening primrose oil, borage oil and black currant oil) results in replacement of AA in the macrophage membrane with EPA or DGLA. The result is production of fewer AA-derived eicosanoids and more EPA- or GLA- derived eicosanoids, thereby reducing the immunologic response to an inflammatory episode. Consequently, changing the type of eicosanoid production and the subsequent alteration in cytokine production can reduce inflammation by eicosanoid-mediated effects. This premise is the basis for using EPA or GLA for treatment of chronic inflammatory conditions.
Use of Fatty Acids for Seborrhea
Campbell and others studied linoleic and other acid levels in dogs with seborrhea. They found with 30 days of supplementation with linoleic acid from sunflower oil clinical signs of seborrhea improved. Transepidermal water loss can be decreased by supplementation with alpha-linolenic acid. Seborrhea sicca is associated with increased transepidermal water loss and can be reversed with linoleic acid.
Use of Fatty Acids for Pruritus
Alpha-linolenic acid (ALA) is a Omega-3 polyunsaturated fatty acid and is metabolized to EPA and DHA, and is part of the skin of normal dogs. Flax seed oil is a rich source of ALA. GLA can be incorporated into the skin where it becomes DGLA and competes with arachidonic acid for metabolic enzymes. The result is decreased arachidonic acid derived eicosanoids and increase in antiflammatory effect. It is believed that up to 50% of dogs with allergic pruritus will be helped by increased fatty acid intake.
From Small Animal Clinical Nutrition: 4th Edition:
Use of Fatty Acids in Inflammatory Diseases: Consumption of fish oil with n-3 PUFA or oils high in the n-6 fatty acid GLA (e.g. evening primrose oil, borage oil and black currant oil) results in replacement of AA in the macrophage membrane with EPA or DGLA. The result is production of fewer AA-derived eicosanoids and more EPA- or GLA- derived eicosanoids, thereby reducing the immunologic response to an inflammatory episode. Consequently, changing the type of eicosanoid production and the subsequent alteration in cytokine production can reduce inflammation by eicosanoid-mediated effects. This premise is the basis for using EPA or GLA for treatment of chronic inflammatory conditions.
Use of Fatty Acids for Seborrhea
Campbell and others studied linoleic and other acid levels in dogs with seborrhea. They found with 30 days of supplementation with linoleic acid from sunflower oil clinical signs of seborrhea improved. Transepidermal water loss can be decreased by supplementation with alpha-linolenic acid. Seborrhea sicca is associated with increased transepidermal water loss and can be reversed with linoleic acid.
Use of Fatty Acids for Pruritus
Alpha-linolenic acid (ALA) is a Omega-3 polyunsaturated fatty acid and is metabolized to EPA and DHA, and is part of the skin of normal dogs. Flax seed oil is a rich source of ALA. GLA can be incorporated into the skin where it becomes DGLA and competes with arachidonic acid for metabolic enzymes. The result is decreased arachidonic acid derived eicosanoids and increase in antiflammatory effect. It is believed that up to 50% of dogs with allergic pruritus will be helped by increased fatty acid intake.
FATTY ACID NUGGETSA convenient highly concentrated source of Omega 3 and Omega 6 fatty acids, Biotin, Vitamins E, A, D3, and Zinc. Most dogs readily accept as a tasty treat. Available in ADL label or your hospital Private Label. Also available in bulk for dispensing in vials and bottles.
CONTENTS: Yellow corn, meat and bone meal, soybean meal, chicken byproduct meal, rice, natural bacon flavor, flax seed oil, source marine lipids concentrated from fish oil, evening primrose oil, borage oil, sunflower oil, soy oil, safflower oil, Biotin 700, Vitamin E, Vitamin A, Vitamin D3, Zinc. Each 3 nuggets contais: 10mg Alpha-linolenic Acid (ALA, Omega 3), 85mg Eicosapentaenoic Acid (EPA, Omega 3), 55mg Docosahexaenoic Acid (DHA, Omega 3), 23mg Gamma-linolenic Acid (GLA, Omega 6), Linoleic Acid (Omega 6), 700µg Biotin AVAILABLE SIZES: 200gm, 500gm, 2kg |
FATTY ACID LIQUIDConcentrated liquids, based on marine lipid concentrates which supply a high level of omega 3 EPA and DHA can make these recommended dosages cost effective for your clients.
As many of the expensive soft gel capsules are punctured and added to the food, the more economical liquid can be used at a higher dosage level. CONTENTS: Marine lipids concentrated from fish oil (source of Omega 3 EPA and DHA), safflower oil, evening primrose oil, borage seed oil (source of Omega 6 Fatty Acids), cod liver oil. Each 1 ml contains: 100 mg EPA, 65mg DHA, 27mg Gamma Linolenic Acid, 390mg Linoleic Acid AVAILABLE SIZES: 8oz, 16oz, Gallon |